To compare the efficacy of Ptprb deletion with Hepta ANGPT1 treatment during SC formation, we generated an inducible Ptprb knockout mouse model using the endothelial specific Cdh5 CreERT2 49 to excise Ptprb from the endothelium of Ptprb flox flox mice 50 at P0 Ptprb О”EC P0 mice, analogous to our studies with Hepta ANGPT1 lasix ototoxicity
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